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FDA clears NeuroXT’s AI software to assess Alzheimer’s progression risk

NeuroXT Inc. has received 510(k) clearance from the U.S. Food and Drug Administration for NEXT-Cue, an AI-based software-as-a-medical-device classified as Class II. NEXT-Cue integrates brain MRI images, demographic information, and cognitive assessment data to provide supplementary information to help clinicians assess patients with mild cognitive impairment for progression to Alzheimer’s dementia within five years. The […] The post FDA clears NeuroXT’s AI software to assess Alzheimer’s progression risk appeared first on Longevity.Technology.

How Some Neuronal Cilia May Affect the Whole Body

A team of researchers has written a paper with a surprising finding: that many of the benefits of caloric restriction and increased NAD+ may be due to their effects on the cilia of hypothalamic neurons. Neuronal cilia have a […]

Topical Urolithin A to Improve Aged Skin Function

Mitochondria are the power plants of the cell, creating the chemical energy store molecule adenosine triphosphate used to power cellular processes. Mitochondrial function declines with age, and the research community is engaged in a variety of approaches that might at least modestly reduce this loss. The supplement urolithin A is known to improve mitochondrial function, though, and as is the case for other approaches, how exactly urolithin A accomplishes this outcome is not fully understood. Most of the ways to modestly improve mitochondrial function, ranging from exercise and calorie restriction through to NAD+ upregulation via vitamin B3 derivatives and MitoQ, may primarily function through improvements to autophagy targeted at mitochondria, improving overall mitochondrial function via improved clearance of damaged and dysfunctional mitochondria. This is by […]

Millions take fish oil for brain health. A two-year study found no benefit

A surprising two-year clinical trial found that fish oil supplements successfully delivered omega-3s to the brain but failed to improve memory or protect against Alzheimer's-related brain shrinkage. Researchers suspect that getting these nutrients through a healthy diet may offer benefits that supplements alone cannot provide.

NeuroXT earns FDA clearance for AI brain scan analyzer for Alzheimer’s

NeuroXT Inc announced that NEXT-Cue, its AI-based Software as a Medical Device supporting prognostic assessment in patients with mild cognitive impairment, has received 510(k) clearance from the U.S. Food and Drug Administration as a Class II medical device. NEXT-Cue integrates brain MRI images, demographic data and cognitive assessment results to provide supplementary information intended to […] The post NeuroXT earns FDA clearance for AI brain scan analyzer for Alzheimer’s appeared first on Longevity.Technology.

Circulating inflammatory biomarkers as adjusted prognostic predictors of post-stroke cognitive impairment: a comparative meta-analysis of cytokines and lymphocyte-based ratio indices in prospective cohorts

IntroductionSystemic inflammation is implicated in post-stroke cognitive impairment (PSCI). Two families of blood markers have been studied as predictors: cytokines (interleukin-6, C-reactive protein) and lymphocyte-based ratio indices from the full blood count, including the neutrophil-to-lymphocyte ratio, the systemic immune-inflammation index (SII) and the globulin-to-lymphocyte ratio (GLR). Existing syntheses pool unadjusted marker differences within a single family, so their relative adjusted associations with PSCI are unknown.MethodsWe systematically reviewed strictly prospective cohorts reporting a covariate-adjusted association between a circulating inflammatory marker and PSCI. Estimates were harmonised to the odds ratio per one standard deviation (SD) increase, deriving SDs where needed from medians and interquartile ranges and rescaling category contrasts by category-spacing f

Oxford Healthspan introduces mixable spermidine supplement

Oxford Healthspan has launched Primeadine GF Spermidine Powder, a mixable gluten-free spermidine supplement announced on 15 October 2026 in Sheridan, Wyoming. The powder expands the Primeadine GF line and offers an alternative to tablets for consumers who prefer adding supplements to food or beverages. Each serving provides 1 mg of whole-food spermidine, which the company […] The post Oxford Healthspan introduces mixable spermidine supplement appeared first on Longevity.Technology.

Elysium launches Balance for perimenopause, menopause support

Elysium has launched Balance, a supplement aimed at perimenopause and menopause that combines Basis with S-equol and ergothioneine to target disruptive symptoms and longer-term health. According to the company, newly published research on Basis showed a significant increase in the estradiol-to-estrone ratio and reported reductions in hot flashes, poor sleep and bloating in an open-label […] The post Elysium launches Balance for perimenopause, menopause support appeared first on Longevity.Technology.

Blocking STING Helps Preserve Bone in Aging Mice

A new study links STING-mediated signals from marrow fat cells to inflammation and declining NAD⁺ levels in bone-forming cells. Interrupting this pathway helped preserve aging bone [1]. […]

Making SIRT1 and NAD+ Therapies Work in People

Reviewers publishing in Biology have elucidated SIRT1 functional reserve as an aspect of aging, describing how its depletion is an upstream cause of age-related […]

Genetic modulation of NAD(P)H homeostasis reveals distinct redox-coupled metabolic vulnerabilities

Scientists find hidden driver of aging and a simple amino acid that fights memory loss in mice

Scientists discovered that declining levels of a protein called Menin may help drive aging, and restoring it in older mice reversed several age-related changes in just 30 days. Even more surprisingly, supplementing with a simple amino acid called D-serine improved memory and learning, offering a potential new approach to age-related cognitive decline.

Scientists warn a popular vitamin D supplement may have a hidden downside

Not all vitamin D supplements are created equal, and new research suggests that one popular form may have an unexpected downside. Scientists found that taking vitamin D2 can actually lower the body's levels of vitamin D3, the form naturally produced by sunlight and more effective at boosting overall vitamin D. Previous studies also suggest that vitamin D3 may provide stronger immune protection against viruses and bacteria.

Vitamin D drug may help crack pancreatic cancer’s protective shield

A vitamin D analog may help break down pancreatic cancer’s protective defenses, potentially making tumors more vulnerable to chemotherapy and immune attack. A small clinical trial found encouraging responses, especially in patients whose tumors had high levels of the vitamin D receptor.

Creatine may help build muscle even without exercise, researchers find

Creatine helped middle-aged adults gain muscle and strength even without a structured workout program in a new 12-week study. When combined with exercise and a calorie-reduced diet, it produced even greater strength gains while helping participants add lean tissue and lose fat. Researchers say the results strengthen the case for creatine as a potentially useful tool for maintaining muscle with age.

Magnesium is essential for health. But can supplements really help with digestion, muscle pain, anxiety and sleep? | Antiviral

Experts cite inconsistent evidence for supplementing with the essential mineral – and warn taking magnesium without a deficiency has risks Read more in the Antiviral series Dietitian Danielle Shine says her Instagram inbox was filled with questions after actor Scarlett Johansson was quoted in the Daily Mail and other publications recently saying she takes magnesium to improve her digestion and sleep. “I know that everybody is taking magnesium now. It’s so helpful,” Johansson reportedly told beauty publication Byrdie. Continue reading...

When supplements don’t make it past the gut

As longevity moves toward increasingly personalized interventions, bioavailability could become as important as the compounds themselves. The longevity industry has become very good at asking what we should take. Less attention is paid to a more basic question: where does it actually go? That’s the core theme of the latest episode of Longevity.Technology UNLOCKED, where […] The post When supplements don’t make it past the gut appeared first on Longevity.Technology.

Pathways Bioscience PB125 improves vascular function in older adults

Pathways Bioscience announced that a randomized, double-blind, placebo-controlled study published in Free Radical Biology and Medicine evaluated PB125 in 20 younger adults and 24 older adults. The company claims two weeks of PB125 supplementation substantially improved vascular endothelial function in older adults, with brachial artery flow-mediated dilation increasing approximately 65% and popliteal artery flow-mediated dilation […] The post Pathways Bioscience PB125 improves vascular function in older adults appeared first on Longevity.Technology.

Glucosamine, a popular joint supplement, linked to faster Alzheimer’s progression

A large health-record analysis found that glucosamine use was associated with a 25% higher likelihood of mild cognitive impairment progressing to dementia. Lab experiments suggest the popular joint supplement may intensify an abnormal sugar-tagging process in the Alzheimer’s brain, although researchers say clinical trials are needed to determine whether it actually causes harm.

Creatine Protects Lean Mass Even Without Exercise

According to a new study, creatine supplementation might help maintain and increase lean mass even without diet or exercise. It also enhanced […]

GLP-1 weight loss and diabetes drugs linked to nutritional deficiencies in nearly 1 in 6 children

Children taking GLP-1 medications (such as Victoza, Saxenda, Trulicity, and Ozempic) for weight loss, prediabetes, or type 2 diabetes may face an overlooked risk: nutritional deficiencies. A new study found that nearly 1 in 6 young patients developed a diagnosed deficiency within a year of starting treatment, with vitamin D deficiency affecting about 12%.

Elivity brings spray-based supplements to Asia

Longevity brand launches a spray tech that skips gut entirely, betting that how a supplement is delivered matters as much as what’s in it. Swallow a supplement, and it’s got a rough trip ahead. Stomach acid, digestive enzymes, a pH environment that keeps shifting – all of it standing between a capsule and your bloodstream. […] The post Elivity brings spray-based supplements to Asia appeared first on Longevity.Technology.

Inducible chronic NAD deficiency in mice reveals multi-systemic phenotypical, metabolic, and transcriptional changes

Olfactory impairment and probable REM sleep behavior disorder in Parkinson’s disease: clinical relevance to the single- and dual-hit hypotheses

BackgroundRapid eye movement (REM) sleep behavior disorder (RBD) and olfactory impairment are common prodromal features of Parkinson’s disease (PD), but the implications of their coexistence remain uncertain. The dual-hit hypothesis proposes concomitant olfactory and enteric involvement, whereas the revised single-hit framework proposes predominantly brain-first or body-first routes. We examined whether probable RBD (pRBD)/anosmia-defined subgroups exhibit distinct clinical profiles.MethodsIn this cross-sectional study, 201 individuals with PD underwent olfactory, cognitive, motor, non-motor, and quality-of-life assessments. Anosmia was defined as a University of Pennsylvania Smell Identification Test score <19 and pRBD as an RBD Screening Questionnaire score ≥6 supplemented by participant and informant interviews. Multivariable models evaluated the main and interactive effects of anosmi

Millions take calcium and vitamin D for bone health. A major review finds little benefit

A sweeping review of more than 153,000 adults found that calcium and vitamin D supplements, alone or together, do little to prevent fractures or falls in most older people. Researchers say the findings challenge routine supplementation for prevention and point instead toward strategies such as balance and resistance exercise.

Elysium opens a clinic built around aging well

The company has launched The Elysium Longevity Institute, a physician-led clinical program meant to bring rigor to a field full of hype. Walk into most longevity clinics, and you’ll find a familiar formula: a long menu of supplements, a handful of peptides, maybe an IV drip, and a sales pitch dressed up as science. Elysium […] The post Elysium opens a clinic built around aging well appeared first on Longevity.Technology.

Canada agrees to help pay for Alzheimer’s drug LEQEMBI

After reconsidering, Canada’s Drug Agency issued a final recommendation supporting public reimbursement of lecanemab, sold as LEQEMBI. Getting a drug approved is the easy half of the job. Getting someone else to pay for it is the half that actually determines who takes it. Canada just cleared that second, harder hurdle for LEQEMBI. On 31 […] The post Canada agrees to help pay for Alzheimer’s drug LEQEMBI appeared first on Longevity.Technology.

Asymptomatic Persistent Infection as a Contribution to Degenerative Aging

Persistent infections such as cytomegalovirus and other herpesviruses most likely accelerate aging, primarily via harmful effects on the immune system that lead to earlier immunosenescence and chronic inflammation than would otherwise be the case. A range of mechanistic and epidemiological research broadly supports this hypothesis. It remains challenging to completely clear persistent viral infections, however. If a strong antiviral therapy existed, epidemiological data would likely prove the point one way or another within five to ten years, as effects on aging would become apparent in older populations. As it stands, the present relatively weak antiviral therapies show some evidence for positive effects on late life risk of mortality and age-related disease, but not in all studies. Asymptomatic infections are traditionally considered harmless, reflecting effective immune […]

Is collagen all hype? – podcast

Collagen powders, gummies and pills have boomed in popularity in recent years boosted by claims that they smooth wrinkles, promote glossy hair and help with joint pain. Amid the noise it can be hard to figure out whether there’s any actual science behind the promise of looking younger for longer. Luckily Dr Xand van Tulleken has spent the past three years writing Make Me Well: a quest to understand the confusing world of wellness, and his chapter on collagen dives deep into the evidence. He tells Madeleine Finlay what collagen does in the body, how we can get it without splashing out on expensive supplements, and why getting to the truth behind wellness claims can be so hard Order Make Me Well from the Guardian Bookshop Support the Guardian: theguardian.com/sciencepod Continue reading...

Scientists discover strange link between low vitamin D and pain

Low vitamin D levels may make recovery from breast cancer surgery more painful, according to a study of 184 women undergoing mastectomy. Patients with vitamin D deficiency were three times more likely to experience moderate to severe pain during the first 24 hours after surgery and also used substantially more of the opioid painkiller tramadol. They received slightly more fentanyl during surgery and experienced more postoperative nausea as well.

What’s actually in the vial?

As longevity clinics multiply and Muse cell branding proliferates, the questions patients aren’t asking could cost them more than money. Walk into a longevity clinic today and the treatment menu has never been longer – peptides, exosomes, NAD+ infusions, and, with increasing frequency, stem cell therapies carrying the language of Muse cell biology. The appetite […] The post What’s actually in the vial? appeared first on Longevity.Technology.

Popular brain supplement linked to shorter lifespan in men

A large study involving more than 270,000 people has linked higher blood levels of the amino acid tyrosine to a shorter lifespan in men. Using both observational data and genetic analysis, researchers found that elevated tyrosine could potentially reduce male life expectancy by nearly a year, while no significant effect appeared in women. Tyrosine is found naturally in protein-rich foods and is also sold as a supplement for boosting focus and mental performance, making the finding especially intriguing.

Stanford scientists discover a seafood that can reverse signs of aging

A substance found in edible sea squirts appeared to reverse several signs of aging in older mice. Plasmalogen supplements improved memory and learning, strengthened connections between brain cells, reduced inflammation, and even helped the mice grow thicker, darker hair. Researchers believe the compounds may encourage brain regeneration and protect aging synapses.

Wie viel bringt Kreatin beim Muskelaufbau?

Der Beitrag Wie viel bringt Kreatin beim Muskelaufbau? erschien zuerst auf quarks.de.

United Therapeutics seeks FDA approval for inhaled treatment for idiopathic pulmonary fibrosis

According to United Therapeutics, the U.S. Food and Drug Administration has accepted a supplemental new drug application for nebulized Tyvaso (treprostinil) inhalation solution to treat idiopathic pulmonary fibrosis, and the company anticipates the agency’s review to be complete in late April 2027. The company claims that, if approved, nebulized Tyvaso would be the first and […] The post United Therapeutics seeks FDA approval for inhaled treatment for idiopathic pulmonary fibrosis appeared first on Longevity.Technology.

Canada recommends public funding for Alzheimer’s drug Leqembi

Biogen Inc. stock drew renewed attention after a Canadian advisory committee issued a final positive recommendation supporting public reimbursement of Leqembi, developed with partner Eisai, for Canadians with mild cognitive impairment or mild dementia due to early Alzheimer’s disease. The recommendation could lead to provincial and territorial funding decisions that expand access in Canada. According […] The post Canada recommends public funding for Alzheimer’s drug Leqembi appeared first on Longevity.Technology.

This common vitamin was linked to 13% better cognitive scores

Older adults with mild cognitive impairment and sleep problems who took at least 5,000 IU of vitamin D daily scored more than 13% higher on a cognitive test than those taking none. The preliminary findings suggest vitamin D could be worth studying as a potentially modifiable factor during an early window of cognitive decline.

Top-selling NAD+ supplement Tru Niagen lands at GNC, Sam’s Club

Niagen Bioscience announced that Tru Niagen is now available at nearly 300 GNC and Sam’s Club retail locations across 44 states and online at both retailers, according to the company. At GNC, the assortment includes Tru Niagen Beauty, which the company describes as the first U.S. beauty supplement featuring Niagen (patented nicotinamide riboside), and Tru […] The post Top-selling NAD+ supplement Tru Niagen lands at GNC, Sam’s Club appeared first on Longevity.Technology.

This common vitamin deficiency becomes far more dangerous when paired with belly fat

A large study of more than 5,500 adults over 50 found a striking combination of risk factors: abdominal obesity paired with vitamin D deficiency was linked to a 123% higher risk of death over six years. Each condition was associated with increased risk on its own, but together they appeared to create a dangerous feedback loop, with belly fat reducing the amount of vitamin D available in the bloodstream while low vitamin D may worsen inflammation and other health problems.

Winona expands menopause care with supplement launch

New launch from Winona reflects a broader shift from symptom relief to supporting women’s long-term healthspan. The longevity industry has searched for the biggest lever to extend healthy lives for years. Much of that conversation has revolved around cells, genes and the molecular mechanics of aging. However, a different question is beginning to surface, and […] The post Winona expands menopause care with supplement launch appeared first on Longevity.Technology.