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Alzheimer’s trial to test drug on people without symptoms to see if it can be prevented

Healthy middle-aged people deemed to be at higher risk of developing condition among those eligible to participate People without memory loss will be offered an experimental Alzheimer’s drug that could stop the development of the condition before dementia symptoms emerge. Healthy middle-aged people deemed to have a higher risk of developing the condition will be eligible to participate in the trial, which is being run by an NHS trust as part of an international clinical trial aiming to prevent dementia. Continue reading...

Early mitochondrial stress reveals potential mechanism for lasting heart protection

Mitochondria are popularly known as the "powerhouse of the cell," but these cellular structures do much more—including acting as signaling hubs. Some signals that mitochondria send can reprogram the activity of the entire cell by switching "on" or "off" different genes through epigenetic changes. Mitochondria's signals can be so effective that, in yeast, fruit flies and worms, mild stress in mitochondria early in life can make the entire organism more resilient and live longer through a process called mitohormesis.

Targeted Reduction of PTBP1 Reverses Cognitive Impairment in a Mouse Model of Alzheimer's Disease

Many of the more sophisticated forms of medicine, including gene therapies and immunotherapies, are challenging to deliver to the brain. At the very least there are far fewer practical options for delivery, and it is possible that none of that that exist fit a given desired use case. The blood-brain barrier stands in the way of intravenous injection as a path for most approaches, blocking passage of most cells and molecules from circulation to brain tissue. While direct injection into the brain or into reservoirs of cerebrospinal fluid can be achieved, they are sufficiently invasive and challenging to rule out commonplace use. The brain is made up of many different cell types, and more sophisticated approaches will want specificity to regions or cell types. Small […]

Pig kidneys just bought humans extra years in eGenesis study

One patient spent nine months off dialysis with a genetically engineered pig kidney before successfully receiving a human transplant. More than 800,000 Americans live with end-stage kidney disease, and the gap between who needs a transplant and who can get one has only widened. Just 28,000 kidney transplants were performed in the U.S. in 2024, […] The post Pig kidneys just bought humans extra years in eGenesis study appeared first on Longevity.Technology.

UK elder-care model targets Asia’s aging boom

VHH brings its ‘village’ model to Malaysia, betting that longevity gains only pay off economically if care reaches everyone. Ask most people what caring for an aging population looks like, and they’ll picture a nursing home: a building you move into when you can no longer live independently, cut off from the life you had […] The post UK elder-care model targets Asia’s aging boom appeared first on Longevity.Technology.

Function connects your lab results to the AI health chatbot you use

Function Health now lets members feed lab results into ChatGPT, Claude and Perplexity, turning AI answers into ones grounded in biology. Millions of people already type their symptoms into an AI chatbot before they type them into a search bar for a doctor’s office. It’s fast, free and available at 2 a.m. when the worry […] The post Function connects your lab results to the AI health chatbot you use appeared first on Longevity.Technology.

Semaglutid bremst Alterungsprozesse bei Mäusen und verlängert die Lebensspanne

Berkeley – Eine regelmäßige Behandlung mit Semaglutid hat die Lebenszeit von älteren Mäusen in vergleichbarem Maße verlängert wie eine gleich starke Kalorienrestriktion ohne Glucagon-like-Peptid-1-Agonisten (GLP-1-Agonisten). Einige Auswirkungen auf die Alterung fielen nach den in Nature (2026; DOI: 10.1038/s41586-026-10940-7) publizierten...[weiter lesen]

Stanford scientists discover a seafood that can reverse signs of aging

A substance found in edible sea squirts appeared to reverse several signs of aging in older mice. Plasmalogen supplements improved memory and learning, strengthened connections between brain cells, reduced inflammation, and even helped the mice grow thicker, darker hair. Researchers believe the compounds may encourage brain regeneration and protect aging synapses.

HCW Biologics wins key U.S. patent protection for hair loss drug

HCW Biologics received a Notice of Allowance from the U.S. Patent and Trademark Office for claims directed to the use of HCW9302 to treat alopecia areata. Together with four recently issued U.S. patents (Nos. 11,401,326; 11,987,619; 12,018,071; 12,516,112) covering compositions, nucleic acids encoding HCW9302, vectors and methods for treating autoimmune diseases, the company says its […] The post HCW Biologics wins key U.S. patent protection for hair loss drug appeared first on Longevity.Technology.

Scribe Therapeutics starts first human trial for cholesterol-lowering gene therapy

Scribe Therapeutics reported second-quarter 2026 financial results and pipeline progress. The company initiated a first-in-human phase 1 clinical trial of STX-1150 in Australia in mid-2026, according to the company, and presented late-breaking non-human primate data at the European Atherosclerosis Society showing up to 90% PCSK9 silencing and LDL-C reductions up to 68%, with a 0.75 […] The post Scribe Therapeutics starts first human trial for cholesterol-lowering gene therapy appeared first on Longevity.Technology.

Rapalogix Health opens Princeton laboratory to advance skin longevity research

Rapalogix Health has established a dedicated research laboratory at Princeton Innovation Center BioLabs in Princeton, New Jersey. According to the company, the facility expands the company’s internal research capabilities and will serve as the primary site for its translational research program into next-generation rapalogs, the proprietary compound class behind Re-Q Health, the company’s professional skincare […] The post Rapalogix Health opens Princeton laboratory to advance skin longevity research appeared first on Longevity.Technology.

China approves Leqembi subcutaneous autoinjector for early Alzheimer’s

China’s National Medical Products Administration approved the subcutaneous autoinjector formulation of LEQEMBI (lecanemab) as an initiation treatment for mild cognitive impairment due to alzheimer’s disease and mild alzheimer’s disease dementia. The approved regimen is 500 mg once weekly, administered as two consecutive 250 mg injections, and patients may switch between intravenous and subcutaneous administration during […] The post China approves Leqembi subcutaneous autoinjector for early Alzheimer’s appeared first on Longevity.Technology.

FibroBiologics granted US patent for fibroblast wound therapy

FibroBiologics, a Houston-based clinical-stage biotechnology company, announced that the United States Patent and Trademark Office issued U.S. Patent No. 12,721,866 on 1 September 2026, covering therapeutic use of fibroblasts in wound healing. The issued claims, the company says, include methods for topically administering compositions comprising 3D spheroid fibroblasts and fibroblast-derived materials such as extracellular vesicles, […] The post FibroBiologics granted US patent for fibroblast wound therapy appeared first on Longevity.Technology.

Mito Health passes one million tests, expands preventive offerings

Mito Health has expanded its direct-to-consumer diagnostics marketplace into seven categories of preventive testing and, according to the company, has run more than one million lab tests. The company claims its catalog now includes more than 1,000 individual lab tests and panels, at-home test kits shipped nationwide, at-home blood draws in 35 states, imaging and […] The post Mito Health passes one million tests, expands preventive offerings appeared first on Longevity.Technology.

Insilico Medicine included in HKEX Tech 100 Index

Insilico Medicine, a clinical-stage drug discovery company powered by generative artificial intelligence, will be included in the HKEX Tech 100 Index following methodology enhancements announced on 18 August 2026 that broaden exposure to emerging technology themes across the AI value chain. The changes will be implemented after the market close on 11 September 2026 and […] The post Insilico Medicine included in HKEX Tech 100 Index appeared first on Longevity.Technology.

Suggesting ERBB4 Overexpression as an Important Mechanism in Alzheimer's Disease

Researchers here suggest that increased ERBB4 expression in neurons is an important driving mechanism in the onset and progression of Alzheimer's disease. One has to be cautious with such findings, even given the effort made by the researchers to show that human data is compatible with the hypothesis, because the mouse models of Alzheimer's disease in which these sorts of discovery are made are very artificial. Mice do not normal exhibit anything like Alzheimer's disease, so the models induce forms of dysfunction that result in something resembling Alzheimer's in humans. The model embodies assumptions about relevant mechanisms that may not be correct, and this is one of the reasons why progress towards therapies has been slow and painful. Single-nucleus RNA-sequencing analysis identified the emergence of […]

Offspring of Centenarians Exhibit Reduced Mortality and Risk of Age-Related Disease

This is far from the only study to indicate that the children of long-lived individuals tend also to be long-lived. The open question is the degree to which this is genetic versus cultural transmission. The construction of very large population databases over the past few decades has produced evidence for genetics to play only a small role in life expectancy for the vast majority of people. Similarly the weight of evidence for lifestyle choice, particularly physical fitness, to be the presently dominant influence on life expectancy is compelling. Against that background, the hypothesis that centenarians are centenarians because they have favorable gene variants that might form the basis for age-slowing therapies faces an uphill battle. Centenarian lifespan extension is frequently accompanied by delayed onset of […]

‘If you can’t understand what sex is, it’s irrelevant if you seem to be enjoying it’: how Queen at Sea upended the dementia drama

Lance Hammer’s first film in 18 years is a heart-wrenching masterpiece about family, mental decline and sexual consent. He and supporting actor Juliette Binoche discuss how they brought unabashed realism to a condition rarely seen on screen The first time we see Martin and Leslie, the elderly couple at the centre of Lance Hammer’s wrenching new film, Queen at Sea, they are walking together up a set of stone steps: one of their regular outings, we assume, in days filled with pottering and quiet companionship. They have their backs to us, and we can’t see their destination beyond a bleached sky that fills the top half of the screen. Symbolically, it may be deemed a bit on the nose: two people near the end of their lives, moving gently towards the white light of oblivion. There’s a whiff of sentimentality about it. But any doubts about this story’s willingness to confront dif

Wie viel bringt Kreatin beim Muskelaufbau?

Der Beitrag Wie viel bringt Kreatin beim Muskelaufbau? erschien zuerst auf quarks.de.

The Last Generation to Die: Interview With Tim Maupin

Filmmaker Tim Maupin has spent a number of years developing The Last Generation to Die, a near-future film about what happens when the first true rejuvenation technologies arrive and who gets left behind. The […]

Senescent Microglia Secrete DLK1, Which Causes Dysfunction in the Aging Brain

Senescent cells accumulate with age in tissues throughout the body, disrupting tissue structure and function with inflammatory secretions. The growing burden of senescent cells is an important contributing cause of degenerative aging. A cell becomes senescent in response to damage induced by some form of stress, or more often when a somatic cell reaches the Hayflick limit on cellular replication. In youth senescent cells are efficiently cleared by the immune system, but immune system aging allows senescent cells to linger and grow in number. Immune cells themselves are prone to reaching the Hayflick limit and entering replicative senescence because they respond to a variety of issues with greater replication to multiply their efforts. Research into neurodegenerative conditions and the state of the aging brain has […]

Healthy aging shaped by more varied biology than previously thought

Molecular changes in aging are far more unique than previously thought, meaning two healthy individuals of identical age can experience significantly different aging journeys.

Veradermics builds $820m war chest for oral hair loss pill

Biotech posts $819.9m war chest and full slate of late-stage trial data as it races to become first FDA-approved oral drug for hair loss. Hair loss has always been treated like a cosmetic footnote in medicine, something to manage quietly rather than a condition worth serious drug development. Dermatologist-founded, late clinical-stage biopharmaceutical company Veradermics is […] The post Veradermics builds $820m war chest for oral hair loss pill appeared first on Longevity.Technology.

Annovis sails past enrollment goal on Alzheimer’s

850 patients signed up for an Alzheimer’s trial needing 760. For a biotech betting everything on one pill, that’s the good kind of surprise. Trial enrollment is the part of drug development nobody writes headlines about. It’s slow, unglamorous and it’s also where a lot of promising drugs quietly die, not because the science failed, […] The post Annovis sails past enrollment goal on Alzheimer’s appeared first on Longevity.Technology.

LifespanningRx launches peptide explorer for clinician-guided reviews

LifespanningRx has launched the Peptide Explorer, an online educational tool designed to help users organize health goals and explore up to three peptide therapy candidates before clinical evaluation. The company says the experience takes about five minutes and uses a structured questionnaire covering areas such as energy and metabolism, body composition, recovery, healthy aging, cognitive […] The post LifespanningRx launches peptide explorer for clinician-guided reviews appeared first on Longevity.Technology.

Minicircle named XPRIZE Healthspan finalist

Minicircle was named one of 10 finalists in the seven-year, $101 million XPRIZE Healthspan competition, placing the Austin, Texas gene therapy developer among contenders seeking measurable rejuvenation in adults aged 50 to 80. The competition drew about 1,400 teams from 58 countries; 600 entries were reviewed, and 40 teams previously received $250,000 to support early […] The post Minicircle named XPRIZE Healthspan finalist appeared first on Longevity.Technology.

United Therapeutics seeks FDA approval for inhaled treatment for idiopathic pulmonary fibrosis

According to United Therapeutics, the U.S. Food and Drug Administration has accepted a supplemental new drug application for nebulized Tyvaso (treprostinil) inhalation solution to treat idiopathic pulmonary fibrosis, and the company anticipates the agency’s review to be complete in late April 2027. The company claims that, if approved, nebulized Tyvaso would be the first and […] The post United Therapeutics seeks FDA approval for inhaled treatment for idiopathic pulmonary fibrosis appeared first on Longevity.Technology.

Diabetes drug metformin could be repurposed to help slow aging mechanisms

Metformin, a widely prescribed, safe and inexpensive drug for type 2 diabetes, is a first-line treatment that lowers blood sugar and improves the body's response to insulin. The drug appears to trick cells into sensing an energy shortage, similar to what happens during fasting or dieting. This activates a key cellular energy sensor called AMPK, which helps trigger cellular waste cleanup and supports cellular repair. Now, a recent review suggests metformin might also help counter some effects of aging.

One immune switch may help drive aging across the body

Aging may be partly fueled by immune cells losing their ability to clear away damaged, inflammation-promoting cells. Blocking a single receptor restored that cleanup process in mice, reducing inflammation and helping their organs, muscles, and memory remain remarkably youthful.

Genome Sequencing of Bat Species in Search of Causes of Longevity

Long-lived bats are extreme outliers in the normal mammalian relationships between species body size, metabolic rate, and life span. They are small, have a high metabolic rate, and unlike near all other mammals with those characteristics, many bat species are long-lived. But bat species do exhibit a very wide range of life spans; near neighbor species can have very different paces of aging. Researchers here sequence the genomes of a number of different bat species in search of insight into the mechanisms driving longevity in bats. As is usually the case, the distant end goal of this sort of comparative biology of aging research is to find potential approaches to the development of longevity therapies. That is a long road, and little progress has been […]

Clonal Hematopoiesis Associates with Idiopathic Pulmonary Fibrosis

Clonal hemotopoiesis is the emergence of patterns of potentially problematic mutations occurring in hematopoietic stem cells that then spread over time throughout the immune system, as these stem cells are the source of all immune cells. It is the most well studied form of the somatic mosaicism that occurs in all tissues, the spread of mutations originating in stem cell populations, with some correlational evidence for it to contribute to the development of other age-related conditions. Here researchers note that clonal hematopoiesis associates with idiopathic pulmonary fibrosis, an age related condition with causes that are poorly understood. The immune system is clearly important to health, but equally the research community is some way from fully understanding how exactly disruptive mutations cause downstream problems in tissues. […]

GLP-1 receptor agonism extends median lifespan in mice

A consensus roadmap from the SENESCENCE2030 network towards precision senescence medicine

Ferroptosis–neuroinflammation interplay: mechanistic pathways and therapeutic opportunities in central nervous system disorders

Oxidative stress, iron dyshomeostasis, and chronic neuroinflammation are the principal mechanisms involved in the progression of central nervous system (CNS) disorders, which are a significant source of death and chronic disability worldwide. This review focuses on understanding the mechanistic relationship between ferroptosis and neuroinflammation in central nervous system (CNS) disorders, which involves the molecular mechanisms, their role in the pathogenesis of the disease, and therapeutic opportunities available. Ferroptosis is a regulated form of cell death triggered by iron-catalyzed lipid peroxidation, glutathione depletion and inactivation of glutathione peroxidase 4 (GPX4), resulting in neuronal injury. The increased generation of ROS in the cell due to the presence of excess iron catalyzes Fenton chemistry, which leads to lipid peroxidation of the cell membrane and ferroptotic

Data-driven subtyping of Parkinson’s disease using MRI: current insights, challenges, and future directions

Parkinson’s disease (PD) is a heterogeneous neurodegenerative disorder marked by diverse motor and non-motor symptom profiles. Traditional symptom-based subtyping shows limited stability and lacks clear biological grounding. Integrating magnetic resonance imaging (MRI) with machine learning (ML) offers a promising avenue for defining biologically informed PD subtypes. This narrative review synthesizes evidence from MRI-based subtyping studies that used structural (T1-weighted), diffusion, functional, or multimodal MRI features as primary inputs for unsupervised or hybrid ML approaches to derive PD subtypes and outlines key methodological challenges and future translational needs. T1-weighted MRI studies consistently identify two to three subtypes characterized by distinct patterns of cortical and subcortical atrophy associated with variation in motor and non-motor symptoms. Although fewe

Multidimensional iron dysmetabolism and gut-brain axis interactions in restless legs syndrome: from peripheral deficiency to central dysregulation

Restless Legs Syndrome (RLS) is a sensorimotor neurological disorder characterized by an irresistible urge to move the lower limbs. Although traditional paradigms attribute its pathogenesis to peripheral iron deficiency, many clinically diagnosed patients present with normal peripheral iron indicators yet exhibit central iron homeostatic dysregulation. This discrepancy highlights a distinct decoupling between peripheral iron stores and central iron availability. The RLS-associated iron metabolic impairment is inherently a complex pathological network orchestrated by multidimensional processes, including intestinal absorption, systemic distribution, blood-brain barrier (BBB) transport, and intracellular utilization. Crucially, gut dysbiosis-induced low-grade enterogenous inflammation may activate the IL-6/hepcidin pathway, thereby sequestering systemically available iron; this mechanism r

Correction: Long non-coding RNAs in glial cells: key drivers of neuroinflammation in cognitive disorders

Engram cell vulnerability in neurodegeneration: from mechanistic insights to therapeutic horizons

Neurodegenerative diseases such as Alzheimer’s disease (AD), Parkinson’s disease (PD), and Huntington’s disease (HD) share progressive memory impairment, yet their upstream pathologies differ. This review synthesizes evidence across these disorders to frame memory decline through engram ensembles and proposes an excitability-vulnerability tradeoff, in which the physiological requirements for engram function, including elevated excitability, synaptic plasticity, and coordinated network activity, also increase sensitivity to synaptic stress, network disruption, and inflammatory perturbations. We summarize disease-related pathological cascades. To date, AD has the most robust body of direct experimental evidence linking pathology to impaired engram function. Solid experimental findings demonstrate that amyloid-β (Aβ)/tau causes hippocampal engram inaccessibility in AD. For PD and HD, infere

Sex hormones in the nucleus incertus: a novel perspective on sex/gender differences in memory and mood dysfunction in Alzheimer’s disease

About 60% of the individuals living with Alzheimer’s disease (AD) in the United States are women. Increasing evidence points to a role for sex hormones, especially estrogen, in making women more vulnerable to AD than men. Several brainstem signaling pathways, as well as multiple neuropeptide modulators and their receptors, are implicated in AD pathology and therapeutic possibilities. However, there is limited research evaluating how the modulatory effects of sex hormones on mood and cognition interact with these brainstem systems. This review seeks to examine possible connections between the nucleus incertus (NI) relaxin-3/relaxin-family peptide receptor 3 (RLN3/RXFP3) system and sex hormone influences in AD to encourage further investigation into how sex hormones may modulate this pathway and contribute to sex differences in disease risk and progression. Understanding how hormone-based

Inflammation and delirium in critically Ill patients: a review

The high prevalence and adverse impact of delirium in critically ill patients necessitate a deeper understanding of its mechanisms. This review explores the pivotal interplay between systemic inflammation and delirium, examining how insults like age, pain and surgery orchestrate neuroinflammation and delirium through microglial activation and blood-brain barrier disruption. Our synthesis identifies a spectrum of inflammatory and neuronal injury biomarkers with prognostic value and evaluates the burgeoning field of anti-inflammatory pharmacotherapy. We conclude that bridging this mechanistic knowledge to clinical practice via biomarker-driven trials is essential for developing effective interventions against delirium.