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Multidimensional iron dysmetabolism and gut-brain axis interactions in restless legs syndrome: from peripheral deficiency to central dysregulation

Restless Legs Syndrome (RLS) is a sensorimotor neurological disorder characterized by an irresistible urge to move the lower limbs. Although traditional paradigms attribute its pathogenesis to peripheral iron deficiency, many clinically diagnosed patients present with normal peripheral iron indicators yet exhibit central iron homeostatic dysregulation. This discrepancy highlights a distinct decoupling between peripheral iron stores and central iron availability. The RLS-associated iron metabolic impairment is inherently a complex pathological network orchestrated by multidimensional processes, including intestinal absorption, systemic distribution, blood-brain barrier (BBB) transport, and intracellular utilization. Crucially, gut dysbiosis-induced low-grade enterogenous inflammation may activate the IL-6/hepcidin pathway, thereby sequestering systemically available iron; this mechanism r

Your sleep may be hiding an early clue to Alzheimer’s

Frequent micro-awakenings during sleep were linked to higher genetic risk for Alzheimer’s in healthy middle-aged adults who had no symptoms. The discovery raises the possibility that subtle changes during sleep could offer an early warning signal years before memory problems appear.

AstronauTx turns sleep into new dementia target

AstronauTx has exercised its Saniona option, advancing a sleep-focused neurodegeneration candidate toward IND-enabling studies. Sleep has become one of the most talked-about levers in longevity science, credited with everything from metabolic health to cognitive resilience. AstronauTx, a UK biotech founded by SV Health’s Dementia Discovery Fund, is now translating that interest into a drug pipeline. […] The post AstronauTx turns sleep into new dementia target appeared first on Longevity.Technology.

Building a health system that puts prevention first

What if your healthcare could connect the dots between your bloodwork, sleep, genetics and everyday life – before something goes wrong? What if healthcare did not begin when you got sick? That question is the center of this week’s episode of Longevity.Technology UNLOCKED, in which ahead of this year’s Longevity Investors Conference, host Phil Newman […] The post Building a health system that puts prevention first appeared first on Longevity.Technology.

Too much or too little sleep may make your body age faster

Both too little and too much sleep may be linked to faster aging throughout the body. Researchers analyzing 23 biological aging clocks found the lowest aging levels among people sleeping about 6.4 to 7.8 hours per day. Short or long sleep was also associated with numerous conditions affecting the brain, heart, lungs, metabolism, and digestive system.

This common vitamin was linked to 13% better cognitive scores

Older adults with mild cognitive impairment and sleep problems who took at least 5,000 IU of vitamin D daily scored more than 13% higher on a cognitive test than those taking none. The preliminary findings suggest vitamin D could be worth studying as a potentially modifiable factor during an early window of cognitive decline.

Whole-body MRI is leaving the biohacker bubble

EHE Health’s partnership with Prenuvo brings boutique preventive scanning and reopens an old debate about who gets access to early detection. For years, whole-body MRI screening has lived in a specific cultural lane: a Silicon Valley biohacker’s routine, a wellness-influencer talking point, a service marketed to people who already track their VO2 max and sleep […] The post Whole-body MRI is leaving the biohacker bubble appeared first on Longevity.Technology.

Enzymedica launches phytosome formulas for sleep, joint support

Enzymedica announced the launch of two Phytosome® formulas, Sleep & Stress Lemon Balm Phytosome and Joint & Muscle PEA Phytosome, expanding the brand’s Phytosome collection. The melatonin-free Sleep & Stress product (SRP $24.99, 60 count) is presented as a vegan, non-habit-forming option for day or night use to support relaxation and restful sleep. Joint & […] The post Enzymedica launches phytosome formulas for sleep, joint support appeared first on Longevity.Technology.

The association between mobility and asleep blood pressure alterations in frail and non-frail adults 80 years and older

Noncircadian BMAL1–YAP activity amplifies persistent inflammation in aged epidermis

AstronauTx secures exclusive global rights to Saniona’s sleep-based neurological drug candidate

AstronauTx has exercised its option under the companies’ 2023 research collaboration and option agreement with Saniona to secure exclusive worldwide rights to research, develop, manufacture and commercialize therapeutic candidates arising from the collaboration. The multi-year collaboration has yielded development candidate ATX0926, which, according to the company, is expected to enter IND-enabling studies shortly. In consideration […] The post AstronauTx secures exclusive global rights to Saniona’s sleep-based neurological drug candidate appeared first on Longevity.Technology.

Scientists discover why poor sleep may harm some brains more

A gene involved in the brain’s overnight cleaning system may change how strongly poor sleep affects Alzheimer’s-related brain changes. The findings point toward more personalized prevention strategies based on both genetics and sleep habits.

AI can tell if your brain is aging faster than you are

A person’s sleeping brain may reveal warning signs of dementia long before memory problems begin. Researchers used machine learning to analyze EEG recordings from about 7,000 adults and found that an older-than-expected “brain age” was tied to a sharply higher dementia risk. Every additional 10 years of brain aging raised that risk by nearly 40%.

Is personalized nutrition worth it?

As personalized nutrition grows, experts argue the smartest health strategy may be simple: test first, supplement second. Walk into any health store or scroll through social media for five minutes and you’ll quickly get the impression that longevity comes in capsule form. Magnesium for sleep. Creatine for strength. Vitamin D for immunity. Electrolytes because your […] The post Is personalized nutrition worth it? appeared first on Longevity.Technology.

Nova Capital commits $100m to back UAE longevity platform

New UAE-backed venture bets future of longevity lies not in standalone wellness brands, but in building ecosystem people never have to leave. In the wellness industry, one app tracks your sleep, another counts your steps, a smartwatch nudges you to stand, your gym has its own membership, your nutrition advice comes from somewhere else and […] The post Nova Capital commits $100m to back UAE longevity platform appeared first on Longevity.Technology.

The next frontier in Alzheimer’s trials? Sleep

Cumulus Neuroscience and Muse bring lab-grade sleep monitoring into patients’ homes, signaling a shift in how brain health may be measured. One of the biggest ironies in sleep research has been that scientists often ask people to sleep in one of the least natural places imaginable: a lab. Hooked up to wires, surrounded by unfamiliar […] The post The next frontier in Alzheimer’s trials? Sleep appeared first on Longevity.Technology.

Alzheimer’s breakthrough: Scientists restore two hours of sleep without clearing brain plaques

Researchers have uncovered a surprising culprit behind sleep loss in Alzheimer’s disease: the brain’s own immune cells. In mice with amyloid plaques, overactive microglia triggered inflammation that kept the brain from getting enough deep, restorative sleep. Temporarily removing most of these cells restored more than two hours of sleep per day, even though the plaques remained unchanged.

Dumbo Health builds a new longevity model for sleep

The startup is betting that the future of longevity isn’t another sleep score, but turning sleep data into physician-led care. Is the Function Health of sleep here? Everyone knows sleep matters. We joke about not getting enough of it, celebrate the rare eight-hour night and buy watches, rings and apps that promise to tell us […] The post Dumbo Health builds a new longevity model for sleep appeared first on Longevity.Technology.