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Semaglutid bremst Alterungsprozesse bei Mäusen und verlängert die Lebensspanne

Berkeley – Eine regelmäßige Behandlung mit Semaglutid hat die Lebenszeit von älteren Mäusen in vergleichbarem Maße verlängert wie eine gleich starke Kalorienrestriktion ohne Glucagon-like-Peptid-1-Agonisten (GLP-1-Agonisten). Einige Auswirkungen auf die Alterung fielen nach den in Nature (2026; DOI: 10.1038/s41586-026-10940-7) publizierten...[weiter lesen]

LifespanningRx launches peptide explorer for clinician-guided reviews

LifespanningRx has launched the Peptide Explorer, an online educational tool designed to help users organize health goals and explore up to three peptide therapy candidates before clinical evaluation. The company says the experience takes about five minutes and uses a structured questionnaire covering areas such as energy and metabolism, body composition, recovery, healthy aging, cognitive […] The post LifespanningRx launches peptide explorer for clinician-guided reviews appeared first on Longevity.Technology.

Diabetes drug metformin could be repurposed to help slow aging mechanisms

Metformin, a widely prescribed, safe and inexpensive drug for type 2 diabetes, is a first-line treatment that lowers blood sugar and improves the body's response to insulin. The drug appears to trick cells into sensing an energy shortage, similar to what happens during fasting or dieting. This activates a key cellular energy sensor called AMPK, which helps trigger cellular waste cleanup and supports cellular repair. Now, a recent review suggests metformin might also help counter some effects of aging.

Genome Sequencing of Bat Species in Search of Causes of Longevity

Long-lived bats are extreme outliers in the normal mammalian relationships between species body size, metabolic rate, and life span. They are small, have a high metabolic rate, and unlike near all other mammals with those characteristics, many bat species are long-lived. But bat species do exhibit a very wide range of life spans; near neighbor species can have very different paces of aging. Researchers here sequence the genomes of a number of different bat species in search of insight into the mechanisms driving longevity in bats. As is usually the case, the distant end goal of this sort of comparative biology of aging research is to find potential approaches to the development of longevity therapies. That is a long road, and little progress has been […]

GLP-1 receptor agonism extends median lifespan in mice

Multidimensional iron dysmetabolism and gut-brain axis interactions in restless legs syndrome: from peripheral deficiency to central dysregulation

Restless Legs Syndrome (RLS) is a sensorimotor neurological disorder characterized by an irresistible urge to move the lower limbs. Although traditional paradigms attribute its pathogenesis to peripheral iron deficiency, many clinically diagnosed patients present with normal peripheral iron indicators yet exhibit central iron homeostatic dysregulation. This discrepancy highlights a distinct decoupling between peripheral iron stores and central iron availability. The RLS-associated iron metabolic impairment is inherently a complex pathological network orchestrated by multidimensional processes, including intestinal absorption, systemic distribution, blood-brain barrier (BBB) transport, and intracellular utilization. Crucially, gut dysbiosis-induced low-grade enterogenous inflammation may activate the IL-6/hepcidin pathway, thereby sequestering systemically available iron; this mechanism r

Senescent Cells in Metabolic Disorders

The most common metabolic diseases, such as type 2 diabetes or fatty liver disease leading to metabolic dysfunction-associated steatohepatitis (MASH), a fibrotic condition of the liver, are consequences of the dysfunctional state of metabolism that results from being overweight and sedentary. These conditions are rare in thin, fit people, even in later life when the damage of aging makes metabolism more vulnerable and inflammatory. Excess visceral fat tissue is known to promote the accumulation of senescent cells. While cells become senescent throughout life, in youth they are promptly cleared by the immune system. That clearance falters with age, allowing senescent cells to linger and accumulate. The metabolic dysfunction produced as a consequence of being overweight accelerates this process. In today's open access paper researchers review […]

AI hunts new uses for Phase 3 metabolic drug

THPharm already has a drug in late-stage trials. Now it’s using AI to work backwards and find out what else that drug might be good for. Drug development usually runs in one direction: pick a disease, search for a molecule that treats it, spend years finding out if you’re right. THPharm, a South Korean biotech […] The post AI hunts new uses for Phase 3 metabolic drug appeared first on Longevity.Technology.

GLP-1 treatment late in life extends lifespan in animal model

A study published in Nature has shown that the GLP-1 drug semaglutide extended the lifespan of older, healthy mice by tempering the detrimental effects of aging. Researchers at the University of California, Berkeley, directly compared the effects of the treatment with those of reduced food intake. They found that the drug mimicked the anti-aging benefits of calorie restriction, conferring even greater benefits in some areas.

An Adiponectin Receptor Agonist Promotes Muscle Growth in Rats

The research community remains very interested in finding novel ways to promote muscle growth with minimal side effects. Therapies that inhibit myostatin or upregulate follistatin signaling are under development, and follistatin gene therapies have been available via medical tourism for some years. But most of the research community is focused on pharmacology, the use of small molecules to influence muscle metabolism. As an example of this type of work, researchers here report on a small molecule that mimics adiponectin signaling to promote muscle growth in rats. Skeletal muscle atrophy is a hallmark of ageing and chronic diseases, yet effective pharmacotherapies remain unavailable. Adiponectin signalling through receptors AdipoR1 and AdipoR2 regulates skeletal muscle metabolism, regeneration and oxidative capacity, but the therapeutic use of adiponectin is limited […]

Exonate rebrands as Foventa Therapeutics to advance diabetic eye drop therapy

Exonate Limited has changed its name to Foventa Therapeutics and shifted its focus to clinical development for non-proliferative diabetic retinopathy. The new name is inspired by the fovea, and the company describes its motto as Simply Sharper. According to the company, Foventa is advancing FOV407, a topical retinal-penetrant small molecule SRPK1 inhibitor designed to act […] The post Exonate rebrands as Foventa Therapeutics to advance diabetic eye drop therapy appeared first on Longevity.Technology.

NorthStrive expands AI program with Yuva to nominate cardiac leads

NorthStrive Biosciences has executed a First Amendment to its Development and License Agreement with Yuva Biosciences to launch a three-phase Expansion Program that will advance four AI-discovered small-molecule compounds toward lead nomination for potential cardiac disease and obesity therapeutics. The Expansion Program is structured to take approximately six months and builds on positive Phase III […] The post NorthStrive expands AI program with Yuva to nominate cardiac leads appeared first on Longevity.Technology.

Can GLP-1 drugs slow ageing? Mouse study shows promise

Fractyl Health’s Revita data show lasting weight loss

One-year trial results show most patients kept off GLP-1-induced weight loss after a single endoscopic procedure. GLP-1 drugs have transformed obesity treatment, but they have also created a new clinical problem: what happens when patients stop taking them. Weight regain after discontinuation is common and well documented, and it has opened a commercial opportunity for […] The post Fractyl Health’s Revita data show lasting weight loss appeared first on Longevity.Technology.

Structural and functional alterations of posterior cingulate cortex subregions in successful cognitive aging

Successful cognitive aging (SCA) describes the preservation of cognitive abilities into advanced age, but its neural basis remains incompletely understood. Metabolic and pathological evidence implicates the posterior cingulate cortex (PCC) as a key region supporting cognitive resilience. However, functionally distinct PCC subregions have rarely been examined using complementary structural, microstructural, and functional imaging measures. In this cross-sectional secondary analysis of publicly available Human Connectome Project in Aging data, we identified 29 adults aged at least 80 years who met successful cognitive aging criteria based on episodic memory and executive function. We selected 29 adults with normal aging (NA) group and 29 middle-aged adults (MA) group matched for sex and education, yielding 87 participants. We combined structural MRI, neurite orientation dispersion and dens

Author Correction: Characterizing the metabolomes of microglia, astrocytes and neurons in ageing and Alzheimer’s brains

Lower order volume, GLP-1 system slump drive down LifeVantage fiscal 2026 sales

LifeVantage reported declines in revenue and earnings for the fourth quarter and full fiscal year 2026. For the quarter ended 30 June 2026, revenue was $42.4 million, down 23.1% year over year; net income per diluted share was $0.10 and adjusted earnings per diluted share were $0.11. Adjusted EBITDA for the quarter was $2.7 million. […] The post Lower order volume, GLP-1 system slump drive down LifeVantage fiscal 2026 sales appeared first on Longevity.Technology.

Dogs may hold surprising clues to human longevity

Dogs and humans may have more in common when it comes to aging than scientists realized. Researchers with the Dog Aging Project found that patterns of small molecules in dogs’ blood were linked to longer or shorter lifespans in remarkably similar ways to those seen in people. These metabolic “fingerprints” could offer clues about the biological processes that drive aging, including metabolism, inflammation, and cellular stress.

AstronauTx turns sleep into new dementia target

AstronauTx has exercised its Saniona option, advancing a sleep-focused neurodegeneration candidate toward IND-enabling studies. Sleep has become one of the most talked-about levers in longevity science, credited with everything from metabolic health to cognitive resilience. AstronauTx, a UK biotech founded by SV Health’s Dementia Discovery Fund, is now translating that interest into a drug pipeline. […] The post AstronauTx turns sleep into new dementia target appeared first on Longevity.Technology.

Short, Intense Exercise Elicits Beneficial Metabolic Changes

A new study compared high-intensity sprint-interval exercise with moderate-intensity exercise. The former produced larger changes in circulating protein and metabolite levels than the latter and stimulated proteins associated with cardiometabolic health benefits [1]. Short and intense vs. […]

Scientists create muscle that exercises itself

Self-contracting myografts improved muscle, bone and metabolic measures in aging mice – without requiring the animals to exercise. Researchers have engineered living muscle grafts that spontaneously contract beneath the skin and appear to reproduce some of exercise’s systemic effects, improving measures of muscle function, bone health and metabolism in aging mice [1]. The work, published […] The post Scientists create muscle that exercises itself appeared first on Longevity.Technology.

A geroprotective probiotic and its functional metabolite counteract inflammaging to extend healthspan

When you eat may matter as much as what you eat for longevity and heart health

What we eat plays a vital role in maintaining a healthy lifestyle. A well-balanced meal rich in essential micronutrients not only fuels the body but may also help protect against metabolic and cardiovascular diseases. There is another question worth asking: Does when we eat matter just as much as what we eat?

Too much or too little sleep may make your body age faster

Both too little and too much sleep may be linked to faster aging throughout the body. Researchers analyzing 23 biological aging clocks found the lowest aging levels among people sleeping about 6.4 to 7.8 hours per day. Short or long sleep was also associated with numerous conditions affecting the brain, heart, lungs, metabolism, and digestive system.

Altimmune’s dual-hormone bet enters Phase 3 trial

Pemvidutide’s balanced glucagon/GLP-1 action heads into pivotal MASH trial, testing if hitting two receptors evenly beats mono-agonist crowd. Altimmune has dosed its first patients in PERFORMA, the Phase 3 trial for pemvidutide in metabolic dysfunction-associated steatohepatitis (MASH) [1]. It’s a milestone moment for a drug that has spent years positioning itself as something other than […] The post Altimmune’s dual-hormone bet enters Phase 3 trial appeared first on Longevity.Technology.

4Moving Biotech targets inflammation in knee osteoarthritis trial

Phase 2a study completes enrollment as biotech tests whether treating joint inflammation could slow osteoarthritis, not just ease pain. Mention GLP-1 today and most people immediately think of weight loss. Drugs like Ozempic and Wegovy have transformed the conversation around obesity and diabetes, becoming some of the biggest medical success stories of the decade. But […] The post 4Moving Biotech targets inflammation in knee osteoarthritis trial appeared first on Longevity.Technology.

Enveda makes ‘exercise pill’ that skips the treadmill

Drug mimics a hormone you make when you push hard at the gym – early results suggest it could help to keep weight off after stopping GLP-1s. There’s a hormone your body releases when you go hard on a run or push through a tough set at the gym. It’s called Lac-Phe, and scientists only […] The post Enveda makes ‘exercise pill’ that skips the treadmill appeared first on Longevity.Technology.

Citrus compound reverses some signs of liver aging in older mice

The liver is a jack-of-all-trades and a master of all. From removing harmful substances and secreting bile to metabolizing proteins, carbohydrates and fats and managing the immune system, the liver does it all. As we age, liver cells undergo major structural changes, making the body prone to metabolic liver diseases such as fatty liver and inflammation, which, over time, can increase the risk of liver cancer.

Greenstone Biosciences awarded funding to advance type 1 diabetes research

Greenstone Biosciences has been awarded a Breakthrough T1D Industry Discovery and Development Partnership grant to develop a type 1 diabetes-derived islet cell platform aimed at understanding and protecting insulin-producing beta cells. The company plans to generate induced pluripotent stem cells from a diverse group of people with type 1 diabetes and to develop three-dimensional pancreatic […] The post Greenstone Biosciences awarded funding to advance type 1 diabetes research appeared first on Longevity.Technology.

Wave Life Sciences targets fat loss without sacrificing muscle

Wave Life Sciences has moved its next-gen obesity therapy into Phase 2, aiming to tackle one of weight loss medicine’s biggest challenges. The obesity drug race has largely been defined by one question: how much weight can people lose? But a growing number of researchers are asking a different one: what kind of weight are […] The post Wave Life Sciences targets fat loss without sacrificing muscle appeared first on Longevity.Technology.

This common vitamin deficiency becomes far more dangerous when paired with belly fat

A large study of more than 5,500 adults over 50 found a striking combination of risk factors: abdominal obesity paired with vitamin D deficiency was linked to a 123% higher risk of death over six years. Each condition was associated with increased risk on its own, but together they appeared to create a dangerous feedback loop, with belly fat reducing the amount of vitamin D available in the bloodstream while low vitamin D may worsen inflammation and other health problems.

Kailera Therapeutics reports Q2 2026 results, updates progress on obesity trials

Kailera Therapeutics reported second quarter 2026 financial results and business updates, highlighting progress across its obesity pipeline. The company reports an active IND for ribupatide oral, with initiation of global Phase 3 obesity trials planned for the first half of 2027, and says its ribupatide injection Phase 2b high-dose obesity trial is fully enrolled with […] The post Kailera Therapeutics reports Q2 2026 results, updates progress on obesity trials appeared first on Longevity.Technology.

UK beats EU and US to first oral GLP-1 approval

MHRA authorize Lilly’s orforglipron tablet for weight management and T2 diabetes, but NHS access still hinges on a NICE decision yet to come. First across the line, not necessarily first to reach patients. On 10 August, the Medicines and Healthcare products Regulatory Agency (MHRA) authorized orforglipron, sold as Foundayo, making the UK the first country […] The post UK beats EU and US to first oral GLP-1 approval appeared first on Longevity.Technology.

For decades, we were told to choose low-fat dairy. New research says otherwise

Full-fat dairy may be healthier than conventional advice has suggested. In a 12-week study, adults who ate three servings a day showed no meaningful increases in weight, body fat, cholesterol, or insulin resistance. They also experienced improved blood pressure and consumed more calcium, protein, and vitamin D. The findings suggest dairy’s complex structure may matter more than its saturated fat content alone.

One-shot FGF21 gene therapy extends mouse healthspan

A single AAV injection protected five organs in aged mice – and raises pointed questions for geroscience, not least how fast it might travel. A single intramuscular injection of gene therapy expressing FGF21 – the metabolic hormone that helps the body decide how to burn and store fuel – has extended both healthspan and lifespan […] The post One-shot FGF21 gene therapy extends mouse healthspan appeared first on Longevity.Technology.

Frontier Bio advances in NIH challenge for AI model

Early success in national $7 million competition highlights how human-cell models could speed up testing for brain therapies. Longevity research has made some remarkable strides in understanding what happens to the aging body. Scientists can increasingly target senescent cells, tweak metabolism, reprogram cells and explore regenerative therapies with growing confidence. But when those same ideas […] The post Frontier Bio advances in NIH challenge for AI model appeared first on Longevity.Technology.

Altimmune starts Phase 3 testing for fatty liver treatment

Altimmune began patient enrollment in the PERFORMA Phase 3 clinical trial, according to the company. The study will evaluate the safety and efficacy of pemvidutide for metabolic dysfunction-associated steatohepatitis. The company claims pemvidutide is a balanced 1:1 dual receptor agonist targeting glucagon and GLP-1 receptors. Pemvidutide is also being investigated for alcohol use disorder and […] The post Altimmune starts Phase 3 testing for fatty liver treatment appeared first on Longevity.Technology.

4Moving Biotech completes phase 2a trial enrollment for knee osteoarthritis treatment

4Moving Biotech has completed enrollment in INFLAM MOTION, an international Phase 2a proof-of-concept study evaluating 4P004, an investigational intra-articular GLP-1 receptor agonist the company claims is first-in-class and designed to address inflammatory mechanisms underlying symptoms and disease progression in knee osteoarthritis. The randomized, double-blind, placebo-controlled trial enrolled 129 patients across Europe, the United States and […] The post 4Moving Biotech completes phase 2a trial enrollment for knee osteoarthritis treatment appeared first on Longevity.Technology.

D&D’s liver drug shows benefits before weight loss

Lancet paper suggests zabopegdutide may act directly on the liver, offering a fresh angle in the race to tackle MASH. One idea that dominated the treatment of metabolic liver disease is this: lose weight, and the liver will follow. However, new data from South Korea-based D&D Pharmatech suggests the story may be more complicated and […] The post D&D’s liver drug shows benefits before weight loss appeared first on Longevity.Technology.

Eating less protein could slow aging, major review finds

A sweeping review of more than 350 studies suggests that the protein boom may be overselling what many people actually need. Eating less protein appears to improve metabolism, reduce inflammation and cellular damage, and activate pathways linked to healthier aging and longer life.